Let's Get Personal


Science, Policy, and Ethics in Personalized Medicine



Welcome - Let's Get Personal!


After a long time of thinking about it (and a long time spent procrastinating), I've decided to resurrect the blog. So I've slapped on a new coat of paint, added a few new gew-gaws, and I'm off to the races.

Sort of.

The blog is now actually an experiment of sorts. I'm waist-deep in writing my thesis, which is a risk prediction system that is able to sit at the heart of a personalized medicine system. It's fascinating work and I'm learning incredible amounts both about the mechanism of making a prediction and about what extra steps are necessary to make an algorithm clinically relevant and doctor friendly.

But the prediction side isn't the only part of personalized medicine that's fascinating. It has the potential to drastically change the way medical care is delivered, but there are a number of hurdles to clear first. Some of those are technological, and some of those are at the heart of my thesis project. But other hurdles are policy issues, economic issues, ethical issues, and privacy issues. I have no way of addressing them (other than VERY briefly) in my thesis, both because they're too far afield, and because I have little expertise in those areas.

I like to think broadly about things, however, and I think that this topic is too important to be considered in isolation. This is something that needs to be discussed publicly, both to allay people's fears and also to take advantage of their wisdom. So that's what I'll be trying to do. I'm going to begin by defining some terms and then we'll see where that takes me.

As I said, this is an experiment, so this will be a little different than a typical blog. The posts will tend to be longer and somewhat less frequent. For now the plan is to publish on Mondays and Thursday, but that may change in the future. For me this blog is going to serve two purposes: 1) to keeping up writing while I'm actually doing the work of the thesis (I've just spent a month writing the first two chapters of my thesis, and I know how much constant practice improves writing, so I want to give myself that practice), and 2) to serve as a testing grounds for ideas to put into a publication on the policy of personalized medicine. I'd love to hear input and comments, so please send me an email (my address is in the sidebar).

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 Interesting Papers

Genetics/Genomics in chronic kidney disease--towards personalized medicine?
Pubmed | Connotea

Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.
Pubmed | Connotea

Laparoscopic Gastrectomy and Personal Genomics: High-Volume Surgeons and Predictive Biomedicine May Govern the Future for Resectable Gastric Cancer.
Pubmed | Connotea

Personalized Medicine: Genetic Variation and Loss of Physiologic Complexity Are Associated With Mortality in 644 Trauma Patients.
Pubmed | Connotea

Using expression and genotype to predict drug response in yeast.
Pubmed | Connotea

Multiplexed Fluorescence Imaging of Tumor Biomarkers in Gene Expression and Protein Levels for Personalized and Predictive Medicine.
Pubmed | Connotea

Comparative effectiveness research and genomic medicine: An evolving partnership for 21st century medicine.
Pubmed | Connotea

Molecular features, markers, drug targets, and prospective targeted therapeutics in cardiac myxoma.
Pubmed | Connotea

Strategies for Therapeutic Repair: The "R" Regenerative Medicine Paradigm.
Pubmed | Connotea

Genetic predisposition to statin myopathy.
Pubmed | Connotea

All Connotea papers tagged "personalized medicine"
All of Reagan's Connotea papers



 Links

Bioinformatics.org
Nodal Point
Flags and Lollipops
Postgenomic
The Gene Sherpas
Eye on DNA
Genetics & Health
The Personal Genome
Omics! Omics!
Science Roll
Genetic Future
The DNA Network
My Biotech Life
Medicine 2.0
Respectful Insolence
The Epistasis Blog


Reagan Kelly is a PhD student at University of Michigan studying bioinformatics. His thesis is focused on risk prediction algorithms for personalized medicine systems, and he is also interested in the policy and societal implications of individualized healthcare.You can read his CV for more information about him. If you would like to contact him, please send an email to reagank -at- reagank.com

You can also read about the purpose of the site, the working the definition of personalized medicine, or just dive in and view all the monthly archives.



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