Let's Get Personal

CURRICULUM VITAE

PERSONAL DATA

EDUCATION

• 1997-2001 Rochester Institute of Technology, B.S. Biology
• 2003-2006 University of Michigan, M.S., Bioinformatics
• 2003-2005 University of Michigan, Ph.D. Pre-Candidate, Bioinformatics
• 2005-Present University of Michigan, Ph.D. Candidate, Bioinformatics

RESEARCH INTERESTS

• Developing flexible and integrative risk prediction systems for use in personalized medicine
• Developing visualization systems that allow interactive exploration of high-dimensional genetic association results
• Developing new strategies to improve the accuracy and performance of genome-wide association studies

RESEARCH EXPERIENCE

• Creating an integrated risk prediction system for use in individualized medicine systems that utilizes clinical, genomic, transcriptomic, proteomic, and metabolomic data

• Developing visualization tools to explore and understand results from genetic association studies
• Investigating the effects of polymorphisms in adrenergic receptors on survival in heart failure patients
• Exploring the genetic architecture that controls the response of lipoprotein phenotypes to triglyceride lowering medication
• Identifying genetic polymorphisms that underlie the response of measures of renal function to angiotensin infusion

• Developed Java code to load localization and function information from Gene Ontology into an XML database
• Developed XQuery statements to test relationships in the database

• Performed protein analysis (SDS-PAGE and Western Blotting) and cell culture
• Analyzed data from 2D gel electrophoresis

• Performed and analyzed time-lapse microscopy experiments to understand differentiation patterns
• Analyzed microarray data to identify genes involved in neural precursor differentiation
• Used bioinformatics and sequence analysis tools to support molecular biology research and trained other researchers in their use
• Maintained, genotyped, and bred a colony of transgenic rats

TEACHING EXPERIENCE

• Genetics of Hypertension. Environmental Health Sciences 513: Pathological Basis of Disease. University of Michigan, 2005.

• Molecular Biology Laboratory Teaching Assistant. Professor: Jean Douthwright. Rochester Institute of Technology, Dec. 2000 - May 2001.
• Demonstrate and explain lab techniques (gel electrophoresis, PCR, plasmid preparation, single colony isolation, sterile technique) to students
• Create, administer, and grade short quizzes about molecular biology concepts and techniques
• Answer student's questions in & out of class
• Monitor student's experiments and safety
• Prepare and maintain stock cultures and laboratory reagents
• Molecular Biology Electronic Teaching Assistant. Professor: Jean Douthwright. Rochester Institute of Technology, Dec. 2000 - May 2001.
• Prepare electronic material to supplement coursework
• Create electronic module quizzes to assess student performance
• Hold online discussion sessions to answer student's questions

FINANCIAL SUPPORT

• Bioinformatics Student Fellowship, Sept. 2003 - Dec. 2004
• Full tuition, stipend, and health insurance for 3 semesters
• Graduate Student Research Assistanceship, Jan. 2005 - Present
• Genetic and Molecular Signaling in Heart Failure, P50HL077101-04
• Principal Investigator: Evangelia Kranias, University of Cincinnati
• Full tuition, stipend, and health insurance for 3 years

PROFESSIONAL SOCIETY MEMBERSHIPS

• International Genetic Epidemiology Society, 2006-2007
• International Society for Computational Biology. 2005

SCIENTIFIC JOURNAL REVIEW

• Bioinformatics

BIBLIOGRAPHY

• Cresci S*, Kelly RJ*, Capolla TP, Diwan A, Dries D, Kardia SLR, Dorn GW. Clinical and Genetic Modifiers of Long-Term Survival in Heart Failure. Journal of the American College of Cardiology. In Press.
• Smith JA, Turner ST, Sun YV, Fornage M, Kelly RJ, Mosley TH, Jack CR, Kullo IJ, Kardia SL. Complexity in the Genetic Architecture of Leukoaraiosis in Hypertensive Sibships from the GENOA Study. BMC Medical Genomics 2009 Apr 7; 2(1):16.
• Kardia SL, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW 2nd, and Liggett SB. Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. BMC Medical Genetics. 2008 Oct 23; 9:93.
• Liggett SB*, Cresci S*, Kelly RJ*, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SLR, and Dorn GW. A polymorphism in GRK5 that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature Medicine 2008 May 1; 14:510-517.
• Smith JA, Arnett DK, Kelly RJ, Ordovas JM, Sun YV, Hopkins, PN, Hixson JE, Straka RJ, Peacock JM, and Kardia SLR. The genetic architecture of fasting plasma triglyceride response to fenofibrate treatment. European Journal of Human Genetics. 2008 Jan 23.
• Liggett SB*, Kelly RJ*, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW. A Functional Polymorphism of the Gαq (GNAQ) Gene is Associated with Accelerated Mortality in African American Heart Failure. Hum Mol Genet. 2007 Nov 15;16(22):2740-50.
• Kelly RJ, Jacobsen DM, Sun YV, Smith JA, Kardia SLR. KGraph: A System for Visualizing and Evaluating Complex Genetic Associations. Bioinformatics 2007 Jan 15; 23(2):249-51. doi: 10.1093/bioinformatics/btl510.

• Kelly RJ, Liggett SB, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW. Functional Polymorphism of the Gαq (GNAQ) Gene is Associated with Accelerated Mortality in African American Heart Failure. Clinical Cardiovascular Genomics, Cold Spring Harbor, NY, October 10-13, 2007.
• Smith JA, Arnett DK, Kelly RJ, Ordovas JM, Sun YV, Hopkins PN, Peacock JM, Kardia SLR. SNP-Risk Factor Interactions Predict Postprandial Triglyceride Response to Fenofibrate. Clinical Cardiovascular Genomics, Cold Spring Harbor, NY, October 10-13, 2007.
• Kelly RJ, Jacobsen DM, Sun YV, Smith JA, Kardia SLR. KGraph: Visualizing and Evaluating Complex Genetic Associations. 15th Annual Meeting of the International Genetic Epidemiology Society (IGES), Tampa Bay, FL, November 16-17, 2006.
• Kelly RJ, Arnett DK, Smith JA, Ordovas JM, Sun YV, Hopkins PN, Peacock JM, Kardia SLR. Interacting genetic factors influencing fasting LDL and HDL response to fenofibrate. 15th Annual Meeting of the International Genetic Epidemiology Society (IGES), Tampa Bay, FL, November 16-17, 2006.
• Smith JA, Arnett DK, Kelly RJ, Ordovas JM, Sun YV, Hopkins PN, Peacock JM, Kardia SLR. Interacting genetic factors influencing fasting VLDL response to fenofibrate. 15th Annual Meeting of the International Genetic Epidemiology Society (IGES), Tampa Bay, FL, November 16-17, 2006.
• Harvey S Hahn, Reagan J Kelly, Ulrich H Frey, Winfried Siffert, Stephen B Liggett, Gerald W Dorn. A Loss of Function Gαq Promoter Polymorphism is Associated with Accelerated Progression of Heart Failure. 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences. Keystone, CO. July 24-27, 2005
• Syed F, Liggett S, Kardia SLR, Kelly R, Case K, Dorn II G, Matkovich S, Piwan A, Odley A, Parekh R, McGuire N, Sparks L, Hahn H. Genetic β-blockade: A G-protein coupled receptor kinase-5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. American Heart Association Scientific Session, Chicago, IL, November 12-15, 2006.

SERVICE

• Biomedical Graduate Student Council
• Bioinformatics Student Representative, 2005
• Webmaster, 2005